RapamycinFungusV1, Main, Exploration, bibRecord, 000119

Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.

Identifieur interne : 000119 ( Main/Exploration ); précédent : 000118; suivant : 000120

Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.

Auteurs : Koji Kasahara [Japon] ; Risa Nakayama [Japon] ; Yuh Shiwa [Japon] ; Yu Kanesaki [Japon] ; Taichiro Ishige [Japon] ; Hirofumi Yoshikawa [Japon] ; Tetsuro Kokubo [Japon]

Source :

PLoS genetics [ 1553-7404 ] ; 2020.

RBID : pubmed:32603360

Descripteurs français

English descriptors

KwdEn :
- Calcineurin (metabolism), Chromatin Immunoprecipitation Sequencing (MeSH), Forkhead Transcription Factors (metabolism), Gene Expression Regulation, Fungal (MeSH), Genes, Fungal (MeSH), High Mobility Group Proteins (genetics), High Mobility Group Proteins (metabolism), Peptidylprolyl Isomerase (genetics), Peptidylprolyl Isomerase (metabolism), Promoter Regions, Genetic (genetics), Protein Binding (genetics), Ribosomal Proteins (genetics), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (growth & development), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (antagonists & inhibitors), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Sirolimus (pharmacology), Tacrolimus (pharmacology), Transcription Factors (antagonists & inhibitors), Transcription Factors (genetics), Transcription Factors (metabolism), Transcription, Genetic (MeSH).
MESH :
- chemical , antagonists & inhibitors : Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , genetics : High Mobility Group Proteins, Peptidylprolyl Isomerase, Ribosomal Proteins, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , metabolism : Calcineurin, Forkhead Transcription Factors, High Mobility Group Proteins, Peptidylprolyl Isomerase, Saccharomyces cerevisiae Proteins, Transcription Factors.
- genetics : Promoter Regions, Genetic, Protein Binding, Saccharomyces cerevisiae.
- growth & development : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae.
- chemical , pharmacology : Sirolimus, Tacrolimus.
- Chromatin Immunoprecipitation Sequencing, Gene Expression Regulation, Fungal, Genes, Fungal, Transcription, Genetic.

Abstract

Fpr1 (FK506-sensitive proline rotamase 1), a protein of the FKBP12 (FK506-binding protein 12 kDa) family in Saccharomyces cerevisiae, is a primary target for the immunosuppressive agents FK506 and rapamycin. Fpr1 inhibits calcineurin and TORC1 (target of rapamycin complex 1) when bound to FK506 and rapamycin, respectively. Although Fpr1 is recognised to play a crucial role in the efficacy of these drugs, its physiological functions remain unclear. In a hmo1Δ (high mobility group family 1-deleted) yeast strain, deletion of FPR1 induced severe growth defects, which could be alleviated by increasing the copy number of RPL25 (ribosome protein of the large subunit 25), suggesting that RPL25 expression was affected in hmo1Δfpr1Δ cells. In the current study, extensive chromatin immunoprecipitation (ChIP) and ChIP-sequencing analyses revealed that Fpr1 associates specifically with the upstream activating sequences of nearly all RPG (ribosomal protein gene) promoters, presumably in a manner dependent on Rap1 (repressor/activator site binding protein 1). Intriguingly, Fpr1 promotes the binding of Fhl1/Ifh1 (forkhead-like 1/interacts with forkhead 1), two key regulators of RPG transcription, to certain RPG promoters independently of and/or cooperatively with Hmo1. Furthermore, mutation analyses of Fpr1 indicated that for transcriptional function on RPG promoters, Fpr1 requires its N-terminal domain and the binding surface for rapamycin, but not peptidyl-prolyl isomerase activity. Notably, Fpr1 orthologues from other species also inhibit TORC1 when bound to rapamycin, but do not regulate transcription in yeast, which suggests that these two functions of Fpr1 are independent of each other.

DOI: 10.1371/journal.pgen.1008865
PubMed: 32603360
PubMed Central: PMC7357790

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcineurin (metabolism)</term>
<term>Chromatin Immunoprecipitation Sequencing (MeSH)</term>
<term>Forkhead Transcription Factors (metabolism)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Genes, Fungal (MeSH)</term>
<term>High Mobility Group Proteins (genetics)</term>
<term>High Mobility Group Proteins (metabolism)</term>
<term>Peptidylprolyl Isomerase (genetics)</term>
<term>Peptidylprolyl Isomerase (metabolism)</term>
<term>Promoter Regions, Genetic (genetics)</term>
<term>Protein Binding (genetics)</term>
<term>Ribosomal Proteins (genetics)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (growth & development)</term>
<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (antagonists & inhibitors)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Sirolimus (pharmacology)</term>
<term>Tacrolimus (pharmacology)</term>
<term>Transcription Factors (antagonists & inhibitors)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
<term>Transcription, Genetic (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Calcineurine (métabolisme)</term>
<term>Facteurs de transcription (antagonistes et inhibiteurs)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Facteurs de transcription Forkhead (métabolisme)</term>
<term>Gènes fongiques (MeSH)</term>
<term>Liaison aux protéines (génétique)</term>
<term>Peptidylpropyl isomerase (génétique)</term>
<term>Peptidylpropyl isomerase (métabolisme)</term>
<term>Protéines HMG (génétique)</term>
<term>Protéines HMG (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (antagonistes et inhibiteurs)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Protéines ribosomiques (génétique)</term>
<term>Régions promotrices (génétique) (génétique)</term>
<term>Régulation de l'expression des gènes fongiques (MeSH)</term>
<term>Saccharomyces cerevisiae (croissance et développement)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Saccharomyces cerevisiae (métabolisme)</term>
<term>Sirolimus (pharmacologie)</term>
<term>Tacrolimus (pharmacologie)</term>
<term>Transcription génétique (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>High Mobility Group Proteins</term>
<term>Peptidylprolyl Isomerase</term>
<term>Ribosomal Proteins</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcineurin</term>
<term>Forkhead Transcription Factors</term>
<term>High Mobility Group Proteins</term>
<term>Peptidylprolyl Isomerase</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Protéines de Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Promoter Regions, Genetic</term>
<term>Protein Binding</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Liaison aux protéines</term>
<term>Peptidylpropyl isomerase</term>
<term>Protéines HMG</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Protéines ribosomiques</term>
<term>Régions promotrices (génétique)</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Calcineurine</term>
<term>Facteurs de transcription</term>
<term>Facteurs de transcription Forkhead</term>
<term>Peptidylpropyl isomerase</term>
<term>Protéines HMG</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Sirolimus</term>
<term>Tacrolimus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Sirolimus</term>
<term>Tacrolimus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Chromatin Immunoprecipitation Sequencing</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Genes, Fungal</term>
<term>Transcription, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Gènes fongiques</term>
<term>Régulation de l'expression des gènes fongiques</term>
<term>Transcription génétique</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Fpr1 (FK506-sensitive proline rotamase 1), a protein of the FKBP12 (FK506-binding protein 12 kDa) family in Saccharomyces cerevisiae, is a primary target for the immunosuppressive agents FK506 and rapamycin. Fpr1 inhibits calcineurin and TORC1 (target of rapamycin complex 1) when bound to FK506 and rapamycin, respectively. Although Fpr1 is recognised to play a crucial role in the efficacy of these drugs, its physiological functions remain unclear. In a hmo1Δ (high mobility group family 1-deleted) yeast strain, deletion of FPR1 induced severe growth defects, which could be alleviated by increasing the copy number of RPL25 (ribosome protein of the large subunit 25), suggesting that RPL25 expression was affected in hmo1Δfpr1Δ cells. In the current study, extensive chromatin immunoprecipitation (ChIP) and ChIP-sequencing analyses revealed that Fpr1 associates specifically with the upstream activating sequences of nearly all RPG (ribosomal protein gene) promoters, presumably in a manner dependent on Rap1 (repressor/activator site binding protein 1). Intriguingly, Fpr1 promotes the binding of Fhl1/Ifh1 (forkhead-like 1/interacts with forkhead 1), two key regulators of RPG transcription, to certain RPG promoters independently of and/or cooperatively with Hmo1. Furthermore, mutation analyses of Fpr1 indicated that for transcriptional function on RPG promoters, Fpr1 requires its N-terminal domain and the binding surface for rapamycin, but not peptidyl-prolyl isomerase activity. Notably, Fpr1 orthologues from other species also inhibit TORC1 when bound to rapamycin, but do not regulate transcription in yeast, which suggests that these two functions of Fpr1 are independent of each other.</div>
</front>
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<Abstract><AbstractText>Fpr1 (FK506-sensitive proline rotamase 1), a protein of the FKBP12 (FK506-binding protein 12 kDa) family in Saccharomyces cerevisiae, is a primary target for the immunosuppressive agents FK506 and rapamycin. Fpr1 inhibits calcineurin and TORC1 (target of rapamycin complex 1) when bound to FK506 and rapamycin, respectively. Although Fpr1 is recognised to play a crucial role in the efficacy of these drugs, its physiological functions remain unclear. In a hmo1Δ (high mobility group family 1-deleted) yeast strain, deletion of FPR1 induced severe growth defects, which could be alleviated by increasing the copy number of RPL25 (ribosome protein of the large subunit 25), suggesting that RPL25 expression was affected in hmo1Δfpr1Δ cells. In the current study, extensive chromatin immunoprecipitation (ChIP) and ChIP-sequencing analyses revealed that Fpr1 associates specifically with the upstream activating sequences of nearly all RPG (ribosomal protein gene) promoters, presumably in a manner dependent on Rap1 (repressor/activator site binding protein 1). Intriguingly, Fpr1 promotes the binding of Fhl1/Ifh1 (forkhead-like 1/interacts with forkhead 1), two key regulators of RPG transcription, to certain RPG promoters independently of and/or cooperatively with Hmo1. Furthermore, mutation analyses of Fpr1 indicated that for transcriptional function on RPG promoters, Fpr1 requires its N-terminal domain and the binding surface for rapamycin, but not peptidyl-prolyl isomerase activity. Notably, Fpr1 orthologues from other species also inhibit TORC1 when bound to rapamycin, but do not regulate transcription in yeast, which suggests that these two functions of Fpr1 are independent of each other.</AbstractText>
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<ForeName>Risa</ForeName>
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<ForeName>Yuh</ForeName>
<Initials>Y</Initials>
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<AffiliationInfo><Affiliation>Department of Molecular Microbiology, Tokyo University of Agriculture, Tokyo, Japan.</Affiliation>
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<ForeName>Yu</ForeName>
<Initials>Y</Initials>
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<AffiliationInfo><Affiliation>Research Institute of Green Science and Technology, Shizuoka University, Shizuoka, Japan.</Affiliation>
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<ForeName>Hirofumi</ForeName>
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<AffiliationInfo><Affiliation>Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan.</Affiliation>
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<Author ValidYN="Y"><LastName>Kokubo</LastName>
<ForeName>Tetsuro</ForeName>
<Initials>T</Initials>
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<AffiliationInfo><Affiliation>Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.</Affiliation>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.

Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae.

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